M65-TFA-DataSheet-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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M65TFA

Cat.No.:HY-P4127A

分⼦式:C₂₀₅H₃₂₆N₆₄O₆₁S₅.xC₂HF₃O₂

Sequence:Cys-Asp-Ala-Thr-Cys-Gln-Phe-Arg-Lys-Ala-Ile-Asp-Asp-Cys-Gln-

Lys-Gln-Ala-His-His-Ser-Asn-Val-Pro-Gly-Asn-Ser-Val-Phe-Lys-G

lu-Cys-Met-Lys-Gln-Lys-Lys-Lys-Glu-Phe-Lys-Ala-NH2(Disulfide

bridge:Cys1-Cys5,Cys14-Cys32)

SequenceCDATCQFRKAIDDCQKQAHHSNVPGNSVFKECMKQKKKEFKA-

Shortening:NH2(Disulfidebridge:Cys1-Cys5,Cys14-Cys32)

作⽤靶点:Others

作⽤通路:Others

储存⽅式:Sealedstorage,awayfrommoisture

Powder-80°C2years

-20°C1year

Insolvent-80°C6months

-20°C1month

溶解性数据

体外实验H2O:≥50mg/mL

*≥meanssoluble,butsaturationunknown.

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造

成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrom

moisture)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。

BIOLOGICALACTIVITY

⽣物活性M65是Maxadilan(61a.a.)的缺失肽，删除了24和42位点之间的残基，是⼀种特异性的PACAP1型受体拮

抗剂，可抑制ANP分泌，并⽤于相关研究[1][2]。

体外研究M65(1µM)completelyblocksthecAMPaccumulationstimulatedby100nMofVIP,andpartiallyinhibitsthe

cAMPaccumulationstimulatedby1nMo