肝酶与生物标志物关联亚临床心肌损伤结构性心脏病佐-6篇28spkx.pdfVIP

ResearchArticle

Theassociationofliverenzymeswithbiomarkers

ofsubclinicalmyocardialdamageandstructuralheartdisease

1,2,⇑1,21,21,21

Mariazo,JonathanRubin,nneM.Clark,JosefCoresh,AndreaL.C.Schneider,

1,2331,2

ChiadiNdumele,RonC.Hoogeveen,ChristieM.Ballantyne,ElizabethSelvin

1DepartmentofMedicine,SchoolofMedicine,JohnsHopkinsUniversity,Baltimore,MD,UnitedStates;2DepartmentofEpidemiologyand

theWelchCenterforPrevention,EpidemiologyandClinicalResearch,JohnsHopkinsBloombergSchoolofPublicHealth,Baltimore,MD,

UnitedStates;3DepartmentofMedicine,SectionofAtherosclerosisandVascularMedicine,BaylorCollegeofMedicine,Houston,TX,UnitedStates

BackgroundAims:PatientswithnonalcoholicfattyliverdisassociationbetweenNTproBNPandbothALTandASTsupports

ease(NAFLD)arethoughttobeatreasedriskofcardiovasculartherecentlydescribedmetabolicroleofnatriureticpeptides.

morbidityandmortality.However,therelationshipsbetween2014EuropeanAssociationfortheStudyoftheLiver.Published

NAFLDandsubclinicalmyocardialinjuryorstructuralheartdisbyElsevierB.V.s.

easeareunknown.

Methods:Weconductedacrosssectionalysisof8668partic

ipantsfromtheAtherosclerosisRiskommunities(ARIC)Study,Introduction

whoshowednoclinicalevidenceofcardiovasculardisease.We

usedl