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DieKinetikderInvertinwirkung
Von
L.MichaelisandMissMaudL.Menten
(Received4February1913.)
With19FiguresinText.
TheKineticsofInvertaseAction
translatedby
12
RogerS.GoodyandKennethA.Johnson
3
Thekineticsofenzyme)actionhaveoftenbeenstudiedusinginvertase,
becausetheeaseofmeasuringitsactivitymeansthatthisparticularenzymeoffers
especiallygoodprospectsofachievingthefinalaimofkineticresearch,namelyto
obtainknowledgeonthenatureofthereactionfromastudyofitsprogress.The
4
mostoutstandingworkonthissubjectisfromDuclaux),Sullivanand
567
Thompson),A.J.Brown)andinparticularV.Henri).Henri’sinvestigationsare
ofparticularimportancesincehesucceeded,startingfromrationalassumptions,in
arrivingatamathematicaldescriptionoftheprogressofenzymaticactionthat
camequiteneartoexperimentalobservationsinmanypoints.Westartfrom
Henri’sconsiderationsinthepresentwork.Thatwehavegonetothelengthsof
reexaminationofthisworkarisesfromthefactthatHenrididnottakeinto
accounttwoaspects,whichmustnowbetakensoseriouslythatanew
investigationiswarranted.Thefirstpointtobetakenintoaccountisthehydrogen
ionconcentration,thesecon
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