比较应用氯氨酮和对乙酰氨基酚来防止接受腹式全子宫切除术的患者中瑞芬太尼所引起的痛觉过敏_0.doc

比较应用氯氨酮和对乙酰氨基酚来防止接受腹式全子宫切除术的患者中瑞芬太尼所引起的痛觉过敏_0.doc

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比较应用氯氨酮和对乙酰氨基酚来防止接受腹式全子宫切除术的患者中瑞芬太尼所引起的痛觉过敏

IntJMedSci.2012;9(5):327333.Publishedonline2012June20.doi:10.7150/ijms.4222PMCID:PMC3384914AComparisonofKetamineandParacetamolforPreventingRemifentanilInducedHyperalgesiainPatientsUndergoingTotalAbdominalHysterectomyNaimeYalcin,1SemaTuncerUzun,2RuhiyeReisli,2HaleBorazan,2,andSerefOtelcioglu2Authorinformation?Articlenotes?CopyrightandLicenseinformation?Goto:ABSTRACTBackground:Theaimofthisprospective,randomized,placebo-controlledstudywastocomparetheeffectsofketamineandparacetamolonpreventingremifentanilinducedhyperalgesia.Methods:Ninetypatientsundergoingtotalabdominalhysterectomywererandomlyassignedtooneofthreegroupstoreceive(I)eithersalineinfusion;(II)0.5mg/kgketamineivbolusor(III)1000mgivparacetamolinfusionbeforeinductionofanesthesia.Untiltheskinclosure,anesthesiawasmaintainedwith0.4g/kg/minremifentanilinfusioninallgroups,additionallyGroupIIreceived5g/kg/minketamineinfusion.Pressurepainthresholdsweremeasuredthedaybeforesurgeryduringthepreoperativevisitforbaselinemeasurementsandrepeatedpostoperativelyat24and48hours(hrs).Pressurepainthresholdswereestablishedbydigitalalgometeronthreedifferentperi-incisionalregionsforcalculatingmeanpressurepainthresholdvalues.Thevisualanaloguescale(VAS),sedationscores,totalmorphineconsumptionandsideeffectswereassessedpostoperatively.Results:Demographiccharacteristics,durationofsurgeryandanesthesiaweresimilarinthethreegroups.Painthresholdsattheincisionregionweresignificantlylowerat24and48hrspostoperativelyinGroupIthantheotherGroups(p0.05).InGroup?,painthresholdswerelowercomparedwithpreoperativebaselinevalues.ThresholdsinGroup??andGroup???werehighercomparedwithpreoperativebaselinevalues(p0.05)TheVA

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