瑞舒伐他汀与缬沙坦联用治疗阵发性房颤合并高血压患者的疗效.docxVIP

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瑞舒伐他汀与缬沙坦联用治疗阵发性房颤合并高血压患者的疗效

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【摘要】目的观察分析缬沙坦与瑞舒伐他汀联合应用治疗阵发性心房颤动合并高血压患者的临床疗效。方法选择我院2018年1月-2019年3月收治的阵发性心房颤动合并高血压患者104例为研究对象，分为联合组与对照组，每组患者52例。对照组采用胺碘酮治疗，联合组在对照组的基础上加用缬沙坦与瑞舒伐他汀联合应用治疗。比较两组的临床疗效以及治疗前后房颤发作次数及发作时间。结果联合组患者的临床治疗总有效率为96.15%，明显高于对照组的80.77%，差异有统计学意义（P0.05）。两组患者治疗后房颤发作次数及发作时间均明显降低，差异有统计学意义（P0.05）。联合组治疗后房颤发作次数及发作时间较对照组降低更加显著，差异有统计学意义（P0.05）。结论缬沙坦以及瑞舒伐他汀联合应用治疗阵发性心房颤动合并高血压患者可以取得满意的临床治疗效果，患者的临床症状得到显著改善，临床广泛推广应用的价值较高。

【关键词】心房颤动；原发性高血压；缬沙坦；瑞舒伐他汀；比索洛尔治疗效果

Efficacyofrosuvastatincombinedwithvalsartaninthetreatmentofpatientswithparoxysmalatrialfibrillationcomplicatedwithhypertension

[abstract]objectivetoobserveandanalyzetheclinicalefficacyofvalsartancombinedwithrosuvastatininthetreatmentofpatientswithparoxysmalatrialfibrillationcombinedwithhypertension.Methods104patientswithparoxysmalatrialfibrillationcombinedwithhypertensionadmittedtoourhospitalfromJanuary2018toMarch2019wereselectedasresearchobjects,andwerepidedintocombinationgroupandcontrolgroup,with52patientsineachgroup.Thecontrolgroupwastreatedwithamiodarone,andthecombinedgroupwastreatedwithvalsartanandrosuvastatinonthebasisofthecontrolgroup.Theclinicalefficacy,frequencyanddurationofatrialfibrillationbeforeandaftertreatmentwerecomparedbetweenthetwogroups.Resultsthetotaleffectiverateofthecombinedgroupwas96.15%,significantlyhigherthanthatofthecontrolgroup(80.77%),andthedifferencewasstatisticallysignificant(P0.05).Aftertreatment,thefrequencyanddurationofatrialfibrillationweresignificantlyreducedinbothgroups,withstatisticallysignificantdifferences(P0.05).Thenumberanddurationofatrialfibrillationinthecombinedgroupweresignificantlylowerthanthoseinthecontrolgroup(P0.05).Conclusionthecombinationofvalsartanandrosuvastatininthetreatmentofpatientswithparoxysmalatrialfibrillationcombinedwithhypertensioncanachievesatisfactoryclinicaltreatmenteffect,theclinicalsymptomsofpatientshavebeensignificantlyimproved,clinicalwideapplicationvalueishigh.

【keywords】atrialfibrillation;Essentialhypertension;Valsartan;Rosuvastatin;Thera