浅论胃癌的临床研究 .pdfVIP

浅论胃癌的临床研究

【摘要】

【关键词】胃肿瘤;青少年;病理学，临床

Abstract:ObjectiveToinvestigatetheclinicalsymptomsandthe

clinico-pathologicalcharacteristicsinyoungpatientswithgastric

carcinoma.MethodsTheclinicalpathologicalrecordsof64young

patients(aged35yearsoryounger)and185elderlypatients(aged60

yearsorolder)wereretrospectivelyanalyzed.Clinicalmanifestation,

Helicobacterpyloriinfection,lesionlocation,diseasecourse,

Borrmanntyping,pathologicaltypeandprognosisbetweenthetwo

groupswereanalyticallycompared.ResultsIntheyouthgroup,there

weremorefemalepatients,theratioofmaletofemalewas1:1.78.

Thereweremorecaseswithepigastriumpain,epigastriumdistendas

thefirstoccurredclinicalmanifestation.Helicobacterpylori

infectioncasesinyouthgroupweresignificantlymorethanthosein

elderlygroup(P0.05).Durationofdiseaseintheyouthgroupwas

lessthan3months,andtheelderlygroupwaslongerthan6months

(P0.01).Thetumorsitesoforiginintheyouthgroupweremainly

locatedingastricsinus,andtheelderlygroupmainlyingastric

cardia(P0.01).Pathologicfeatures,BorrmannⅢorⅣandpoorly

differentiatedadenocarcinomawereprevalentintheyouthgroup,and

welldifferentiatedadenocarcinomawereprevalentintheelderly

group(P0.01orP0.05).The5-yearsurvivalratewasobviouslylower

intheyouthgroupthanthatinelderlygroup(P0.05).Conclusion

Comparedtotheelderly,youngpatientswithgastriccarcinomascarry

worsedegree,lowerdifferentiation,fasterprogressandpoorer

prognosis.Earlyidentification,radicalresectiontreatmentare

necessarytoimprovecurativeandsurvivalratesforyoungpatients.

Keywords:stomachneoplasms;adolescence;pathology,clinical

胃癌是世界范围内最常见的恶性肿瘤之一，位居癌症死因的第二位[1]。其

发病高峰为50～70岁，近年来青年人胃癌有增多趋势。而青年人胃癌又有其特

殊性，多呈浸润性生长，侵袭力强，转移率高，预后差。为了解青年人胃癌临

床病理特征，现对我院有完整临床资料的64例青年胃癌患者的临床病理及预后

与同期老年胃癌患者作对比分析，报告如下。