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***ThisslideshowsthestudydesignfortheE4599phaseIIItrialofcarboplatin/paclitaxelwithorwithoutAvastinasfirst-linetherapyforNSCLC.ThiswasamulticentrerandomisedtrialcarriedoutbytheEasternCooperativeOncologyGroup(ECOG)in78sitesintheUSA,PuertoRicoandSouthAfrica.Randomisationwasstratifiedbymeasurabilityofdisease(yesorno),diseasestage(IIIB/IV/recurrent),presenceorabsenceofpriorradiationtherapy,andamountofpriorweightloss(≧5%or5%)Patientsweretreateduntildiseaseprogression(asassessedbytheinvestigator)orunacceptabletoxicity.PatientsintheCP-alonearmwerenotpermittedtocrossovertoreceiveAvastinatdiseaseprogression.ReferenceSandlerA,GrayR,PerryMC,etal.Paclitaxel-carboplatinaloneorwithbevacizumabfornon-small-celllungcancer.NEngJMed2006;355:2542-50.**Amongthe878patientsrandomised,698deathshadoccurredatthetimeofthefinalanalysis.TheKaplan-MeiercurveshownheredemonstratestheeffectofaddingAvastintoCPonoverallsurvival.1AsignificantincreaseinmedianoverallsurvivalwasobservedinpatientsreceivingAvastin+CPcomparedwithCPalone
(12.3monthsvs10.3months).TheHRfordeathwas0.79(p=0.003).Thisisthefirst,randomisedphaseIIItrialinNSCLCinwhichthemedianoverallsurvivalhasexceeded1year.Inaddition,thisisthefirststudycombiningabiologicaltherapywithchemotherapythathasshownanimprovementinoverallsurvivalinfirst-lineNSCLC.Inlightofthesefindings,thestudyauthorssuggestthatAvastin+CPshouldbeconsideredanewstandardofcareforpatientswithadvancedNSCLCwithdiseasecharacteristicsthatmakethemsuitabletoreceiveAvastin.ReferenceSandlerA,GrayR,PerryMC,etal.Paclitaxel-carboplatinaloneorwithbevacizumabfornon-small-celllungcancer.NEngJMed2006;355:2542-50.**ReferenceSandlerA,GrayR,PerryMC,etal.Paclitaxel-carboplatinaloneor
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