Setmelanotide-monoacetate-RM-493-monoacetate-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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Setmelanotidemonoacetate

Cat.No.:HY-19870C

CASNo.:2759937-80-7

Synonyms:RM-493monoacetate;BIM-22493monoacetate;IRC-022493

monoacetate

分⼦式:C₅₁H₇₂N₁₈O₁₁S₂

分⼦量:1177.36

作⽤靶点:MelanocortinReceptor

作⽤通路:GPCR/GProtein;NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Setmelanotide(monoacetate)是⼀种⿊⽪质素4受体(MC4R)激动剂，作⽤于⼈和⼤⿏MC4R，EC50分别为

0.27nM和0.28nM[1][2]。

客户使⽤本产品发表的科研⽂献

•JExpMed.2021Jul5;218(7):

•MolMetab.2024Sep10:102027.

•CellRep.2022Nov1;41(5):111579.

•JMedChem.2017Nov9;60(21):8716-8730.

•JMedChem.2017Nov9;60(21):8716-8730.

Seemorecustomervalidationsonwww.MedChemE

REFERENCES

[1].KumarKG,etal.AnalysisofthetherapeuticfunctionsofnovelmelanocortinreceptoragonistsinMC3R-andMC4R-deficientC57BL/6J

mice.Peptides.2009Oct;30(10):1892-900.

[2].KievitP,etal.Chronictreatmentwithamelanocortin-4rece