CPI1-生命科学试剂-MCE.pdf

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

CPI1

Cat.No.:HY-P10856

分⼦式:C₁₁₁H₁₃₁N₂₃O₃₀S

分⼦量:2299.43

Sequence:Cyclo(Ac-{d-Tyr}-Phe-Trp-Gly-Asn-Leu-His-Trp-Tyr-Tyr-Glu-Gl

n-Phe-Asp-Ser-Thr-Cys)

SequenceShortening:Cyclo(Ac-{d-Tyr}-FWGNLHWYYEQFDSTC)

作⽤靶点:P-glycoprotein

作⽤通路:MembraneTransporter/IonChannel

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性CPI1是⼀种有效的且⾼特异性的多药耐药蛋⽩1(MRP1)抑制剂。CPI1对MRP1具有纳摩尔级的抑制活性(Ki:

100nM)，对P-糖蛋⽩(Pgp)的抑制作⽤很⼩。CPI1与LTC4竞争结合MRP1的同⼀位点，抑制ATP⽔解和底

物转运。CPI1可⽤于药物递送和癌症化疗耐药性的研究。

IC50TargetKi:100nM(MRP1)[1]

REFERENCES

[1].PietzHL,etal.AmacrocyclicpeptideinhibitortrapsMRP1inacatalyticallyincompetentconformation.ProcNatlAcadSciUSA.2023

Mar14;120(11):e2220012120.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

Tel:400-820-3792;021Fax:021E-ma