N36Mut-e-g-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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N36Mut(e,g)

Cat.No.:HY-P10820

分⼦式:C₁₈₉H₃₁₇N₅₅O₅₆

分⼦量:4255.87

Sequence:Ser-Gly-Ile-Asp-Gln-Glu-Gln-Asn-Asn-Leu-Thr-Arg-Leu-Ile-Glu

-Ala-Gln-Ile-His-Glu-Leu-Gln-Leu-Thr-Gln-Trp-Lys-Ile-Lys-Gln-

Leu-Leu-Ala-Arg-Ile-Leu

SequenceShortening:SGIDQEQNNLTRLIEAQIHELQLTQWKIKQLLARIL

作⽤靶点:HIV

作⽤通路:Anti-infection

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性N36Mut(e,g)是⼀种针对gp41的HIV融合肽抑制剂。N36Mut(e,g)通过破坏前发夹中间体中N端螺旋的同源

三聚体卷曲螺旋形成异源三聚体⽽起作⽤。

REFERENCES

[1].BewleyCA,etal.DesignofanovelpeptideinhibitorofHIVfusionthatdisruptstheinternaltrimericcoiled-coilofgp41.JBiolChem.

2002Apr19;277(16):14238-45.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

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