乙肝病毒表面抗原阳性孕妇母婴阻断效果评价及影响因素分析 .pdf

乙肝病毒表面抗原阳性孕妇母婴阻畛果评价及影响因素分析

【摘要】目的：分析乙肝病毒表面抗原(HBsAg)阳性孕妇母婴阻断效果及相关响因素。方法：收集2020年1

月-2023年12月惠山区预防梅毒、乙肝母婴传播工作月报表和乙肝表面抗原阳性孕产妇及所分娩儿童服务情况一览表，

对222例HBsAg阳性孕妇及所分娩新生儿的资料进行分析，儿童8月龄之后采集血液，检测儿童乙肝血清学指标评价

母婴阻断效果，采取单因素与多因素Logistic回顾分析阻断效果的相关响因素。结果：222例儿童25例(11.26%)

HBsAg阳性，201例(90.54%)抗-HBs阳性，10例(4.50%)抗-HBc阳性。多因素Logistic回归分析显示HBsAg

阳性持续时间长(OR=1.562)、未同时接种乙肝疫苗与乙肝免疫球蛋白(OR=2.041)和母乳喂养(OR=1.884)均是

HBsAg阳性孕妇母婴阻断效果的危险因素。结论：HBsAg阳性孕妇的母婴阻断效果受HBsAg阳性持续时间、未同时接

种疫苗和免疫球蛋白、母乳喂养等因素响。

【关键词】乙肝病毒表面抗原；阳性；孕妇；母婴阻断；响因素

Evauationofmother-to-chidbockadeeffectofHBsAgpositivepregnantwomenandanaysisofinfuencing

factors

WANGZhe

MaternaandChidHeathandFamiyPanningServiceCenterofHuishanDistrict,WuxiCity,Wuxi,Jiangsu

214100,China

［Abstract］Objective：Toanayzethemother-to-chidbockadeeffectofhepatitisBvirussurfaceantigen

(HBsAg)positivepregnantwomenandreatedinfuencingfactors.Methods：Themonthyreportonthepreventionof

syphiisandhepatitisBmother-to-chidtransmissioninHuishanDistrictfromJanuary2020toDecember2023andthe

istofservicesforhepatitisBsurfaceantigen-positivepregnantwomenandtheirchidrenwerecoected,andthedata

of222HBsAg-positivepregnantwomenandtheirnewbornswereanayzed,andtheboodwascoectedaftertheage

of8months,andtheseroogicaindexesofhepatitisBinchidrenweretestedtoevauatethemother-to-chidbocking

effect,andthereevantinfuencingfactorsofthebockingeffectwereanayzedbyunivariateandmutivariateogistic

retrospectivey.ResuIts:25cases(11.26%)of222chidrenwereHBsAgpositive,201cases(90.54%)were

positiveforantiHBs,and10cases(4.50%)werepositiveforanti-HBc.MutivariateLogisticregressionanaysis

showedthattheongdurationofHBsAgp