颅内动脉支架术后再狭窄的血液影响因素分析与探讨.pdfVIP

颅内动脉支架术后再狭窄的血液影响因素分析

与探讨

Analysis and Discussion of Blood Factors Affecting Intracranial 

Artery In-Stent Restenosis

□吴瀚博WUHan-bo高莹GAOYing

摘要Abstract

目的探讨颅内动脉狭窄支架置入术后相关血液生物标志物与进行性动脉粥样硬化再狭窄的关系。方法选取

2020年1月—2022年8月在我院进行颅内动脉狭窄支架置入术的140例患者为研究对象。统计术后12个月随访

期间症状性颅内动脉狭窄支架置入术后复发性缺血性脑血管事件的发生情况，将其分为复发性/缺血性卒中(n=15)

和非复发性/缺血性卒(n=125)。对随访期间血液生物指标及症状等进行统计学分析。结果在单因素分析中，平均

p

血小板体积等与复发性/脑缺血事件相关(0.05)。多元Logistic回归分析提示，支架内再狭窄(ISR)是复发性/缺

血性卒中发生的重要危险因素。结论ISR是发生复发性卒中或短暂性脑缺血发作的重要危险因素，而术后测试的

血液生物标志物与ISR正相关。

ObjectiveToinvestigatetherelationshipbetweenrelatedbloodbiomarkersandprogressiveatheroscleroticrestenosis

afterstentimplantationforintracranialarterystenosis.MethodsAtotalof140patientswhounderwentstentingfor

intracranialarterystenosisinourhospitalfromJanuary2020toAugust2022wereselectedforthestudy.Theoccurrence

ofrecurrentischemiccerebrovasculareventsaftersymptomaticintracranialarterystenosisstentingduringthe12-month

postoperativefollow-upperiodwascountedandclassifiedintorecurrent/ischemicstroke(n=15)andnon-recurrent/ischemic

stroke(n=125).Statisticalanalysisofbiologicalindicatorsandsymptomsduringthefollow-upperiodwasperformed.

ResultsInunivariateanalysis,meanplateletvolumewasassociatedwithrecurrent/ischemicevents(p0.05).Multiple

logisticregressionanalysissuggestedthatin-stentrestenosis(ISR)wasasignificantriskfactorforrecurrent/ischemicstroke.

ConclusionsISRisanimportantriskfactorforthedevelopmentofrecurrentstrokeortransientischemicattack,andblood

biomarkerstestedaftersurgeryarepositivelyassociatedwithISR.

关键词 Key words：颅内动脉粥样硬化性狭窄Intracranialatheroscleroticstenosis；支架置入术Stentimplantation；