射波刀治疗老年早期非小细胞肺癌的治疗效果与安全性.docx

射波刀治疗老年早期非小细胞肺癌的治疗效果与安全性

李雪汪延明田芹张弘旺

[中图分类号]?R734.2；R730.55????[文献标识码]?A????[DOI]?10.3969/j.issn.1673-9701.2024.05.012

Efficacy?and?safety?of?cyberknife?in?the?treatment?of?elderly?patients?with?early?stage?non-small?cell?lung?cancer

LI?Xue1，2，?WANG?Yanming2，?TIAN?Qin3，?ZHANG?Hongwang1，2

1.Postgraduate?Training?Base?of?960th?Hospital?of?PLA，?Jinzhou?Medical?University，?Jinzhou?121012，?Liaoning，?China;?2.Department?of?Radiation?Oncology，?960th?Hospital?of?PLA，?Jinan?250031，?Shandong，?China;?3.Department?of?Radiation?Oncology，?Shandong?Provincial?Third?Hospital，?Jinan?250031，?Shandong，?China

[Abstract]?Objective?To?investigate?the?efficacy?and?safety?of?Cyberknife?in?the?treatment?of?elderly?patients?（aged≥75?years）?with?early?stage?non-small?cell?lung?cancer?（NSCLC），?and?to?compare?the?results?with?those?of?patients?aged?75?years.?Methods?We?retrospectively?analyzed?75?patients?with?early?（T1-2N0M0）?NSCLC?admitted?to?the?960th?Hospital?of?Jinan?Peoples?Liberation?Army?from?January?2013?to?October?2019.?There?were?32?（42.7%）?patients?aged?75?years，?and?43?（57.3%）?patients?aged≥75?years.?All?patients?were?treated?with?45–66Gy/3–8F，?60%–85%?isodose?line?as?the?prescription?dose?to?cover?planning?target?volume?（PTV），?and?irradiation?once?a?day?and?five?times?a?week.?The?clinical?efficacy，?survival?status?and?radiotherapy?toxicity?of?the?two?groups?were?compared，?and?the?factors?affecting?the?efficacy?of?elderly?patients?were?analyzed.?Results?The?disease?control?rates?of?patients?aged??75?and?≥75?years?were?96.9%?and?93.0%，?respectively?（P0.05）.?The?5-year?local?control?rate?（LC），?progression-free?survival?（PFS）?and?cancer-specific?survival?（CSS）?were?70.9%?and?85.4%，?58.5%?and?54.4%，?and?70.4%?and?64.5%，?respectively?（P0.05）.?However，?the?overall?survival?（OS）?of?patients?aged≥75?years?was?significantly?lower?than?that?of?patients?aged?75?years，?and?the?5-year?OS?was?49.2%?and?68.2%，?respectively?（P0.05）.?There?was?no?significant?difference?in?the?treatment?compli