生长激素协同高孕激素促排卵方案对低预后女性体外受精结局的影响.docx

生长激素协同高孕激素促排卵方案对低预后女性体外受精结局的影响

张加能张焕焕王冲

[关键词]?生长激素；体外受精；高孕激素促排卵；低预后；倾向得分匹配

[中图分类号]?R711????[文献标识码]?A????[DOI]?10.3969/j.issn.1673-9701.2024.05.002

Effects?of?growth?hormone?co-treatment?with?progesterone-primed?ovarian?stimulation?protocol?on?IVF?outcomes?in?women?with?low?prognosis

ZHANG?Jianeng，?ZHANG?Huanhuan，?WANG?Chong

Reproductive?Endocrinology?Center，?Hangzhou?Womens?Hospital，?Hangzhou?310000，?Zhejiang，?China

[Abstract]?Objective?To?study?the?effect?of?growth?hormone?（GH）?with?progesterone-primed?ovarian?stimulation?（PPOS）?protocol?on?in?vitro?fertilization?（IVF）?outcomes?among?women?with?low?prognosis.?Methods?This?is?a?retrospective?cohort?study?using?propensity?score?matching?（PSM）?analysis.?Women?commencing?their?IVF?between?January2017?to?December2021，?with?and?without?GH?co-treatment，?were?reviewed.?Results?After?PSM，?76?pairs?of?women?with?low?prognosis?were?included?into?analysis.?Paired?testing?showed?there?is?a?statistical?increase?in?transferable?embryo?（P0.001）?in?the?GH?co-treatment?group?comparing?with?control?group.No?significant?difference?showed?in?retrieved?oocyte?number?and?metaphaseⅡ（MⅡ）?oocyte?rate，?two-pronuclear?（2PN）?zygote?rate?on?day1，?high-quality?embryo?rate，?or?clinical?pregnancy?rate，?neither?in?gonadotropin?（Gn）?requirement?，?duration?or?peak?estradiol.?Subgroup?analysis?results?showed?transferrable?embryo?rate?on?day3?rising?among?decreased?ovarian?reserve?women?（P=0.010）.?For?women?aged?below?40，?MⅡoocyte?rate?（P=0.010）?and?transferrable?embryo?rate?on?day3?（P0.001）?increased?in?GH?co-treatment?group.?Conclusions?GH?is?suggested?a?beneficial?impact?on?oocyte?quality?and?transferrable?embryos?with?PPOS?protocol?in?IVF.?Its?adjuvant?administration?can?be?proposed?as?an?optional?therapeutic?strategy?in?women?with?low?prognosis.

[Key?words]?Growth?hormone;?In?vitro?fertilization;?Progesterone-primed?ovarian?stimulation;?Low?prognosis;?Propensity?score?matching

然而，由于在患者类型选择、GH治疗时机或GH应用的最佳剂量方面缺乏共识，GH在改善IVF结局方面的有效性仍存在争议。本研究旨在通过P