绝经BPPV患者血清25(OH)D3、血钙与骨代谢变化及意义.docx

绝经BPPV患者血清25(OH)D3、血钙与骨代谢变化及意义

朱小云李晓波吴春红

[关键词]?绝经女性；良性阵发性位置性眩晕；25-羟维生素D3；血钙；骨代谢

[中图分类号]?R271.116；R764??????[文献标识码]?A????[DOI]?10.3969/j.issn.1673-9701.2024.04.012

Changes?and?significance?of?serum?25（OH）D3，?blood?calcium?and?bone?metabolism?in?menopausal?women?with?BPPV

ZHU?Xiaoyun，?LI?Xiaobo，?WU?Chunhong

Department?of?Neurology，?Hangzhou?Ninth?Peoples?Hospital，?Hangzhou?311200，?Zhejiang，?China

[Abstract]?Objective?To?investigate?the?changes?and?clinical?significance?of?serum?25-hydroxyvitamin?D3[25（OH）D3]，?blood?calcium?and?bone?metabolism?indexes?in?menopausal?women?with?benign?paroxysmal?positional?vertigo?（BPPV）.?Methods?A?total?of?103?menopausal?BPPV?patients?from?Hangzhou?Ninth?Peoples?Hospital?from?August?2020?to?August?2021?were?enrolled?into?BPPV?group.?According?to?the?one-year?recurrence?situation，?they?were?divided?into?recurrence?group?（n=18）?and?non-recurrence?group?（n=85）.?A?total?of?50?healthy?menopausal?women?during?the?same?period?were?enrolled?as?control?group.?The?clinical?data，?serum?25（OH）D3，?calcium?and?bone?metabolism?indexes?[procollagen?typeⅠN-terminal?propeptide?（PINP），?N-terminal?midfragment?of?osteocalcin?（N-MID），?β-isomerised?C-terminal?telopeptide?of?collagen?typeⅠ（β-CTX），?bone?alkaline?phosphatase?（BALP）]?were?collected.?Logistic?regression?model?was?constructed?to?analyze?the?risk?factors?of?BPPV?in?menopausal?women.?The?predictive?value?of?related?indexes?for?BPPV?recurrence?was?analyzed?by?receiver?operating?characteristic?curves.?Results?The?serum?25（OH）D3?level?in?BPPV?group?was?significantly?lower?than?that?in?control?group?（P0.05），?and?the?proportion?of?long-term?irregular?diet，?PINP，?N-MID?and?BALP?levels?were?significantly?higher?than?those?in?control?group?（P0.05）.?Multivariate?Logistic?regression?analysis?showed?that?low?25（OH）D3，?high?PINP，?high?N-MID?and?high?BALP?were?all?risk?factors?for?BPPV?in?menopausal?women?（P0.05）.?The?25（OH）D3?level?in?recurrence?group?was?significantly?lower?than?that?in?non-recurrence?group