Canertinib-Standard-CI-1033-Standard-生命科学试剂-MCE.pdf

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Canertinib(Standard)

Cat.No.:HY-10367R

CASNo.:267243-28-7

Synonyms:CI-1033(Standard);PD-183805(Standard)

分⼦式:C₂₄H₂₅ClFN₅O₃

分⼦量:485.94

作⽤靶点:EGFR;Orthopoxvirus

作⽤通路:JAK/STATSignaling;ProteinTyrosineKinase/RTK;Anti-

infection

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Canertinib(Standard)是Canertinib的分析标准品。本产品⽤于研究及分析应⽤。Canertinib(CI-1033;PD-

183805)是有效的，不可逆的EGFR抑制剂；抑制细胞EGFR和ErbB2⾃⾝磷酸化的IC50值分别为7.4和9

nM。Canertinib可以⽤于研究⼩⿏的⽜痘病毒呼吸道感染。

IC50TargetIC50:7.4nM(EGFR),9nM(ErbB2)[1]

REFERENCES

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(phenylamino)quinazoline-and4-(phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamidesbearingadditionalsolubilizingfunctions.JMedChem.

2000Apr6;43(7):1380-97.

[2].DjerfSeverinssonEA,etal.Thepan-ErbBreceptortyrosinekinaseinhibitorcanertini