telomerase signaling端粒酶信号传导.pdfVIP

CanonicalPathway

ReportDate:2016-01-17

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ContentVersion:(ReleaseDate:2015-11-30)

CanonicalTelomeraseSignaling

Pathway:

Description:Theextendedgrowthpotentialofcancercellsiscriticallydependentuponthemaintenanceoffunctionaltelomeres,whicharesectionsofDNAoccurring

attheendsofeachchromosomeinaeukaryoticcell.TelomeresconsistofhighlyrepetitivesequencesofDNAthatdonotcodeforproteins,butfunction

ascapstokeepchromosomesfromfusingtogether.Inordertodivide,anormalcellhastoreplicatetheentireDNAinitschromosomes.However,thelast

fewbasesonthetelomerearenotcopiedwitheachroundofDNAreplicationasacellages,whichresultsintelomereshorteningwitheachroundofcell

division.Atonepoint,cellsstopgoingthroughcelldivision,andthishaltingrowthistriggeredbygenesthatareactivatedinresponsetoDNAdamage

suchasp53.AtelomerethatbecomestooshortnolongerprotectsthechromosomefromDNAdamage.Cellreplicationisstoppedandthecellisforced

intosenescence.

Telomericstructuralproteinsfallintotwogeneralgroups:thosethatbindtelomericDNAdirectly,andthosethatinteract,directlyorindirectly,withthe

telomericDNA-bindingproteins.SometelomericDNA-bindingproteinsbindsingle-strandedtelomericDNAandothersbindduplextelomericDNA.The

telomeraseribonucleoprotein