酒渣鼻的发病机制和治疗相关性.pdfVIP

1229365CMSXXX10.1177/12034754241229365JournalofCutaneousMedicineandSurgeryGengetal

review-article2024

ReviewArticle

JournalofCutaneousMedicineandSurgery

2024,Vol.28(2)178–189

Rosacea:PathogenesisandTherapeutic©TheAuthor(s)2024

Correlates

/10.1177/12034754241229365

DOI:10.1177/12034754241229365

12

RyanS.Q.Geng,MSc,AdriennN.Bourkas,MSc,

3

AsfandyarMufti,MD,FRCPC,

andR.GarySibbald,MD,MEd,FRCPC,MACP,FAAD,

MAPWCA,DSc(Hons)1,4

Abstract

Rosaceaisachronicinflammatoryconditionofwhichthereisnocure.Thepathogenesisofrosaceaislikelymultifactorial,

involvinggeneticandenvironmentalcontributions.Currentunderstandingsuggeststhatpro-inflammatorypathwaysinvolving

cathelicidinsandinflammasomecomplexesarecentraltorosaceapathogenesis.Commonrosaceatriggersmodulatethese