高血压脑出血血清Nogo-A、Adropin、CysC水平与近期预后的关系分析.pdfVIP

JOURNALOFRAREANDUNCOMMONDISEASES,MAY.2025,Vol.32,No.5,TotalNo.190

·论著·

高血压脑出血血清Nogo-A、Adropin、CysC水平与近期预后的关系

分析

*

吴中华王炬娄平阳王成光

河南省人民医院神经外科(河南郑州450001)

【摘要】

目的探究高血压脑出血患者血清神经轴突生长抑制因子A(Nogo-A)、Adropin、胱抑素C(CysC)水平的检测意义。方法80例高血压脑出血患者被纳入本

院治疗作为研究组，另选取42例单纯高血压患者为对照组。比较两组血清Nogo-A、Adropin和CysC水平，根据改良Rankin量表将研究组分为预后良好组(n=49)

及预后不良组(n=31)，并对上述指标进行比较，以Logistic回归分析对上述指标与患者近期预后的关系进行分析。结果研究组Nogo-A、CysC水平高于对照

组，Adropin水平低于对照组，差异显著(P0.05)。预后不良组Nogo-A、CysC水平高于预后良好组，Adropin水平低于预后良好组，差异显著(P0.05)。Nogo-

A≥157.918ng/mL、Adropin2.068ng/mL、CysC2.354mg/L是预测患者预后不良的危险因素。结论血清Nogo-A、CysC、Adropin均与高血压脑出血的发生及

出血量有密切关联，且三者对患者预后均有预测价值。

【关键词】高血压脑出血；神经轴突生长抑制因子A；Adropin蛋白；胱抑素C

【中图分类号】R743.2

【文献标识码】A

DOI:10.3969/j.issn.1009-3257.2025.5.010

RelationshipbetweenSerumNogo-A,Adropin,CysCand

Short-termPrognosisinPatientswithHypertensiveCerebral

Hemorrhage

*

WUZhong-hua,WANGJu,LOUPing-yang,WANGCheng-guang.

DepartmentofNeurosurgery,HenanProvincialPeoplesHospital,Zhengzhou450001,HenanProvince,China

Abstract:ObjectiveThisstudyaimstoassessthediagnosticsignificanceofserumNogo-A,Adropin,andCysCinhypertensivecerebralhemorrhagepatients.

Methods80patientswithhypertensivecerebralhemorrhageand42withsimplehypertensionwereassignedtostudyandcontrolgroups,respectively,to

compareserumNogo-A,Adropin,andCysClevels.Studygrouppatientswerefurtherdividedintogood(n=49)andpoor(n=31)prognosisgroupsbased

onmodifiedRankinscalescoresforindexcomparison.Logisticregressionanalyzedtheassociationbetweenthesebiomarkersandshort-termprognosis..

ResultsThestudygroupexhibitedelevatedNogo-AandCysClevelsandreducedAdropincomparedtothecontrolgroup(P0.05).Similarly,thepoor

prognosisgrouphadhigherNogo-AandCysC,andlowerAdropinthanthegoodprognosisgroup(P0.05).Nogo-A≥157.918n