1-4-Pip-Ph-DHP-dione-生命科学试剂-MCE.pdfVIP

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1-(4-Pip-Ph)-DHP-dione

Cat.No.:HY-W761300

CASNo.:2446913-96-6

分⼦式:C₁₄H₁₈N₄O₂

分⼦量:274.32

作⽤靶点:LigandsforE3Ligase

作⽤通路:PROTAC

储存⽅式:4°C,protectfromlight

*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)

BIOLOGICALACTIVITY

⽣物活性1-(4-Pip-Ph)-DHP-dione是⼀种E3连接酶配体(E3ligaseligand)。1-(4-Pip-Ph)-DHP-dione可⽤于合成

PROTACHPK1Degrader-2(HY-162544)[1]。

REFERENCES

[1].BeiGene,Ltd.Preparationofpyrrolo[2,3-b]pyrazine-basedbifunctionalcompoundsasHPK1degradersandtheusethereof.World

IntellectualPropertyOrganization,WO2023006063A12023-02-02.

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