强化降压：从循证证据到临床实践的多维考量.pdfVIP

心电心电与与循环循年第年第4444卷第卷第44期期

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强化降压：从循证证据到临床实践的

多维考量

徐少坤张丽陈晨谢建洪

[摘要]本文旨在探讨强化降压策略在高血压管理中的应用，从循证医学证据出发，结合国内外最新指南推荐，分析强化降

压的临床获益与风险，并对特殊人群的血压控制目标的个体化考量作一介绍。通过系统梳理近年来的关键临床试验和荟萃分析

结果，本文强调了在患者耐受的前提下，将血压控制至更低目标（＜130/80mmHg，1mmHg=0.133kPa）对于降低心血管事件

和死亡风险的重要性。同时，本文还关注了强化降压在老年患者、妊娠期高血压患者等特殊人群中的应用，并提出了相应的管理

建议，以期为临床实践提供科学指导，优化高血压患者的治疗效果。

[关键词]强化降压；循证医学证据；特殊人群管理

Intensivebloodpressurelowering:fromevidence-basedmedicinetoclinicalpractice

XUShaokun,ZHANGLi,CHENChen,XIEJianhong

Authorsaddress:DepartmentofGeriatrics,ZhejiangProvincialPeoplesHospital,Hangzhou310014,China

Correspondingauthor:XIEJianhong,E-mail:Jhongxie@163.com

[Abstract]Thisarticleaimstoexploretheapplicationofintensivebloodpressureloweringstrategiesin

hypertensionmanagement.Basedonevidencefromevidence-basedmedicineandincorporatingthelatest

guidelinesfrombothdomesticandinternationalsources,itanalyzestheclinicalbenefitsandrisksofintensiveblood

pressurecontrol,withafocusonindividualizedtargetsforspecificpopulations.Bysystematicallyreviewingrecent

keyclinicaltrialsandmeta-analyses,thearticlehighlightstheimportanceofachievinglowerbloodpressuretargets

(＜130/80mmHg,1mmHg=0.133kPa)inreducingcardiovasculareventsandmortality,providedpatienttoleranceis

ensured.Furthermore,itaddressestheapplicationofintensivebloodpressurecontrolinspecialpopulationssuchasthe

elderlyandpregnantwomenwithhypertension,andofferscorrespondingmanagementrecommendations.Thegoalisto

providescientificguidanceforclinicalpracticeandoptimizetreatmentoutcomesforpatientswithhypertension.

[Keywords]Intensivebloodpressurelowering;Evidence-based