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Troponin-IN-1

Cat.No.:HY-175640

分⼦式:C₂₂H₃₀O₅

分⼦量:374.47

作⽤靶点:Pyroptosis;ReactiveOxygenSpecies(ROS);Interleukin

Related;Caspase

作⽤通路:Apoptosis;Immunology/Inflammation;Metabolic

Enzyme/Protease;NF-κB

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Troponin-IN-1是⼀种肌钙蛋⽩(troponin)抑制剂。Troponin-IN-1通过减少LDH泄漏、细胞焦亡(

pyroptosis)和活性氧(ROS)积累，保护OGD/R损伤的H9c2⼼肌细胞。Troponin-IN-1在LPS(HY-D1056)诱

导的RAW264.7细胞中抑制NO产⽣以及IL-1β、TNF-α和IL-18的释放。Troponin-IN-1通过caspase-

1/GSDMD/IL-18信号通路发挥作⽤。Troponin-IN-1在LAD诱导的⼼肌缺⾎/再灌注(MI/R)雄性⼤⿏模型中减

少⼼肌梗死⾯积。Troponin-IN-1可⽤于研究⼼肌缺⾎/再灌注损伤[1]。

体外研究Troponin-IN-1(Compound19)(0.1-10μM,24h)enhancesviabilityofOGD/R-injuredH9c2cardiomyocytes,

reducesLDHleakageandinhibitsROSaccumulation[1].

Troponin-IN-1(10-50μM)decreasespyroptoticH9c2cells,maintainscellmorphologyandblockspyroptosis

byinhibitingcaspase-1/GSDMD/IL-18pathway[1].

Troponin-IN-1(6.25-100μM,pretreatmentfor30min)inhibitsNOproductioninLPS(HY-D1056)-induced

RAW264.7cells(IC50=13.49