细胞核结构与调控机制及核孔复合体功能.pdfVIP

THECELLNUCLEUS

核膜结构

Structure:Double-membranenuclearenvelopesurroundsthenucleus

Thenuclearenvelopeconsistsoftwomembranes,theouteronebeingcontinuouswiththe

endoreticulummembrane,itiscontinuouswiththespaceweenthetwonuclear

membranes.Thelipidbilayersoftheinnerandouternuclearmembranesareconnectedateach

nuclearpore.Twonetworksofintermediatefilamentsprovidemechanicalsupportforthenuclear

envelope;theintermediatefilamentsinsidethenucleusformaspecialsupportingstructurecalled

thenuclearlamina

核膜调控机制(破裂,磷酸化)

TheNuclearEnvelopeIsDisassembledDuringMitosis.Thephosphorylationofthe

laminsisthoughttotriggerthedisassemblyofthenuclearlamina,whichinturncauses

thenuclearenvelopetobreakup.Dephosphorylationofthelaminsisthoughttohelp

toreversetheprocess.

8，9页核孔结构，大小

EachNPCcontainsoneormoreopenaqueouschannels:9nmindiameterand15nm

long

GAP,GEF调节哪些生理活动

看图说话

关联以下的物质进出核方式

核小体组成成分；

Anucleosomecontainsaproteincore(madeofeighthistonemolecu)and200bp

多级螺旋模型and骨架模型

两种异的含义和区别

HeterochromatinDividedintotwoclasses:

Constitutive结构异染色质：Compactedstateatalltime:Centromere

Facultative兼性异染色质：Inactivatedatcertainphaseoflife

TheGiantChromosomes:

LampbrushChromosomesContainLoopsofDecondensedChromatin

PolyteneChromosomes:AreArrangedinAlternatingBandsandInterbands

Functionsofnucleolus:RibosomalBiogenesis50页自己看去

52，53页核糖体构成；核糖体形成方式：自己看去。。。。

TheCytoskeleton1

TheTubulinSubunits组成(α-,β-特点)

•α-tubulin:BoundGTP.Nothydrolysed.Non-exchangable.

•β-tubulin:BoundGDP.E