5-Ethynyl-2-deoxyuridine-13C2-EdU-sup-13-sup-C-sub-2-sub-生命科学试剂-MCE.pdfVIP

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5-Ethynyl-2-deoxyuridine-13C2

Cat.No.:HY-118411S1

CASNo.:1610530-35-2

Synonyms:EdU-13C2

分⼦式:C₉₁₃C₂H₁₂N₂O₅

分⼦量:254.21

作⽤靶点:Isotope-LabeledCompounds;PROTACLinkers

作⽤通路:Others;PROTAC

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性5-Ethynyl-2-deoxyuridine-13C2(EdU-13C2)是13C标记的5-Ethynyl-2-deoxyuridine(HY-118411)。5-

Ethynyl-2-deoxyuridine(EdU)是⼀种胸腺嘧啶核苷类似物，在细胞增殖时能够插⼊正在复制的DNA分⼦中

，EdU与染料的共轭反应可以进⾏⾼效快速的细胞增殖检测分析。5-Ethynyl-2-deoxyuridine是⼀种PROTAC

linker，属于alkylchain类。可⽤于合成PROTAC分⼦。5-Ethynyl-2-deoxyuridine是⼀种点击化学试剂。它

含有Alkyne基团，可以和含有Azide基团的分⼦发⽣铜催化的叠氮-炔环加成反应(CuAAc)。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

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