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D-Cateslytin

Cat.No.:HY-P11170

CASNo.:3002053-77-9

分⼦式:C₈₁H₁₃₀N₃₀O₁₉S

分⼦量:1860.15

Sequence:d-{Arg-Ser-Met-Arg-Leu-Ser-Phe-Arg-Ala-Arg-Gly-Tyr-Gly-Phe

-Arg}

SequenceShortening:d{RSMRLSFRARGYGFR}

作⽤靶点:Fungal

作⽤通路:Anti-infection

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性D-Cateslytin是⼀种抗菌肽，对⽩⾊念珠菌具有强效抑菌活性(MIC=2.9μM)。D-Cateslytin能快速进⼊⽩⾊

念珠菌细胞，对⼈⽛龈成纤维细胞⽆细胞毒性，且在唾液中保持稳定。D-Cateslytin可⽤于研究⽩⾊念珠菌相

关疾病，例如⼝腔念珠菌病的研究[1]。

体外研究D-Cateslytin(0-100μg/mL,24-72h)showsnocytotoxicitytohumangingivalfibroblasts(HFG-1)after72

hoursforconcentrationsupto100μg/mL[1].

D-Cateslytin(100-123μM,24h)remainsstableinthesupernatantofCandidaalbicans,andremainsstable

inhumansaliva[1].

CellCytotoxicityAssay[1]

CellLine:HFG-1cells

Concentration:0-100μg/mL

IncubationTime:24,48and72h

Result:ShowednocytotoxicityonHGF-1after72hoursforconcentrationsupto100μg/mL.

REFERENCES

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