DBM-819-生命科学试剂-MCE.pdfVIP

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DBM-819

Cat.No.:HY-126751

CASNo.:331686-58-9

分⼦式:C₂₃H₂₇N₃O₂

分⼦量:377.48

作⽤靶点:Na+/K+ATPase

作⽤通路:MembraneTransporter/IonChannel

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性DBM-819是⼀种可逆性的H/K-ATP酶(H+/K+-ATPase)抑制剂，其IC50为5μM。DBM-819通过抑制胃

粘膜中的质⼦泵，可逆性阻断胃酸分泌。DBM-819对Cysteamine(HY-77591)诱导的⼗⼆指肠溃疡、

Indomethacin(HY-14397)和Aspirin(HY-14654)诱导的胃溃疡均表现出显著保护作⽤，EC50值分别为6、

3.1和4mg/kg。DBM-819可⽤于抗溃疡研究。

REFERENCES

[1].ChoiSJ,etal.InvitrometabolismofanewH(+)/K(+)ATPaseinhibitorDBM-819inlivermicrosomesusingHPLCandelectrospraymass

spectrometry.BiomedChromatogr.2001Dec;15(8):503-6.

[2].KimEJ,etal.Dose-dependentpharmacokineticsofanewreversibleprotonpumpinhibitor,DBM-819,afterintravenousandoral

administrationtorats:hepaticfirst-passeffect.BiopharmDrugDispos.2001Apr;22(3):119-28.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.