cCBD-LL37-生命科学试剂-MCE.pdfVIP

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cCBD-LL37

Cat.No.:HY-P11457

CASNo.:2378579-44-1

分⼦式:C₂₈₂H₄₆₆N₈₂O₈₂

分⼦量:6317.22

Sequence:Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-L

ys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-

Glu-Ser-Asp-Tyr-Lys-Asp-Asp-Asp-Asp-Lys-Thr-Lys-Lys-Thr-Leu-Arg-Thr

SequenceLLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTESDYKDDDDKTKKTLRT

Shortening:

作⽤靶点:Bacterial

作⽤通路:Anti-infection

储存⽅式:Pleasestoretheproductundertherecommendedconditionsinthe

CertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性cCBD-LL37是⼀种经胶原结合域(cCBD)(TKKTLRT)修饰的嵌合抗菌肽。cCBD-LL37在PBS洗涤和不同静电条

件下均能更好地保留在胶原蛋⽩上。cCBD-LL37与胶原蛋⽩的结合涉及特异性和⾮特异性相互作⽤，由长程静

电⼒引发，随后转变为近程或疏⽔相互作⽤。cCBD-LL37具有强效抗菌活性，并在不同的离⼦强度和pH条件

(pH5.5-8)均具有稳定结构稳定。cCBD-LL37可⽤于胶原蛋⽩基伤⼝敷料等⽣物材料研究[1]。

REFERENCES

[1].WeiZ,etal.CharacterizationofLL37BindingtoCollagenthroughPeptideModificationwithaCollagen-BindingDomain.ACSOmega.

2023Sep14;8(38):35370-35381.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.