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Mer/c-Met-IN-1

Cat.No.:HY-178438

CASNo.:3062159-91-2

分⼦式:C₃₈H₃₈FN₇O₄

分⼦量:675.75

作⽤靶点:c-Met/HGFR;Apoptosis

作⽤通路:ProteinTyrosineKinase/RTK;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Mer/c-Met-IN-1是⼀种强效的Mer/c-met双抑制剂，其IC50值分别为1nM和19nM。Mer/c-Met-IN-1能够

抑制癌细胞的增殖、迁移并诱导凋亡(apoptosis)。Mer/c-Met-IN-1可⽤于癌症研究，如结肠癌[1]。

体外研究Mer/c-Met-IN-1exhibitsrobustantiproliferativeactivityagainstHCT116,A2780,andPC-3cancercelllines

withIC50valuesof1.01μM,0.96μM,and3.42μMrespectively[1].

Mer/c-Met-IN-1showsfavorablemetabolicstabilityinhumanlivermicrosomeswithahalf-life(t1/2)of72.6

minandaclearancerate(CL)of0.05mL/min/mg[1].

Mer/c-Met-IN-1exhibitsnegligibleinhibitiononhERGpotassiumchannelswithanIC50value40μM[1].

Mer/c-Met-IN-1(0.4-3.2μM,48h)inducesdose-dependentapoptosisinHCT116cellswithanED50of1.368

pM[1].

Mer/c-Met-IN-1(0.8-20μM,24h)significantlysuppressesthemigrationofHCT116cells[1].

ApoptosisAnalysis[1]