2025 AHA科学声明：血培养阴性心内膜炎.pdfVIP

JournaloftheAmericanHeartAssociation

AHASCIENTIFICSTATEMENT

BloodCulture–NegativeEndocarditis:

A

ScientificStatementFromtheAmerican

HeartAssociation

EndorsedbytheInternationalSocietyforCardiovascularInfectiousDiseases

DanielC.

DeSimone,MD,FAHA,Chair;ZereldaEsquerGarrigos,MD,FAHA,ViceChair;GraceE.Marx,MD,MPH;

PierreTattevin,MD,FAHA;BarbaraHasse,MD;DavidW.McCormick,MD,FAHA;MargaretM.Hannan,MD;

LieslJ.Zuhlke,MD;ConnieS.Radke,MSN,NP,FAHA;LarryM.Baddour,FAHA;onbehalfoftheAmerican

HeartAssociationCouncilonLifelongCongenitalHeartDiseaseandHeartHealthintheYoung;Councilon

ClinicalCardiology;andCouncilonQualityofCareandOutcomesResearch

ABSTRACT:Bloodculture–negativeendocarditishasbeenassociatedwithworseoutcomeswhencomparedwithbloodcul-

ture–positiveendocarditis,becausepathogen-directedantimicrobialtherapyandothermanagementaspectshavebeendif-

ficulttoachieve.Noveldiagnostictools,however,havechangedthelandscapeofthissyndromeandwilllikelyimprovepatient

outcomes.ThisAmericanHeartAssociationscientificstatementhighlightstheseadvances.Thewritinggroup,whichrepre-

sentsamultidisciplinaryteam,providesanupdateonbloodculture–negativeendocarditis.Clinicalscenariosrepresentativeof

real-worldexperiencesareincludedtoassistfrontlinecliniciansinthediagnosisandmanagementofthissyndrome.

KeyWords:AHAScientificStatements■bloodculture–negativeinfectiveendocarditis■diagnosis■management■prevention

positivebloodcultureisamajorclinicalcriterionDeterminingthecauseofBCNEinthesettingof

forconfirminginfectiveendocarditis(IE)andisrecentantimicrobialexposureinvolvesconsideration

AoftenthefirstcluethatIEmaybeconsideredinofavarietyoffactors.Theseincludee