2024+AHA科学声明：心脏对大脑健康的贡献.pdfVIP

Stroke

AHASCIENTIFICSTATEMENT

CardiacContributionstoBrainHealth:

AScientificStatementFromtheAmerican

HeartAssociation

FernandoD.Testai,MD,PhD,FAHA,Chair;PhilipB.Gorelick,MD,MPH,FAHA,ViceChair;Pei-YingChuang,PhD,EMBA,MSN,RN;

XingDai,MD;KarenL.Furie,MD,FAHA;RebeccaF.Gottesman,MD,PhD,FAHA;JoseC.Iturrizaga,MD,FAHA;

RonaldM.Lazar,PhD,FAHA;AndreaM.Russo,MD,FAHA;SudhaSeshadri,MD;ElaineY.Wan,MD,FAHA;onbehalfofthe

AmericanHeartAssociationStrokeCouncil;CouncilonCardiopulmonary,CriticalCare,PerioperativeandResuscitation;Council

onCardiovascularandStrokeNursing;andCouncilonHypertension

ABSTRACT:Theburdenofneurologicdiseases,includingstrokeanddementia,isexpectedtogrowsubstantiallyinthe

comingdecades.Thus,achievingoptimalbrainhealthhasbeenidentifiedasapublichealthpriorityandamajorchallenge.

CardiovasculardiseasesaretheleadingcauseofdeathanddisabilityintheUnitedStatesandaroundtheworld.Emerging

evidenceshowsthattheheartandthebrain,onceconsideredunrelatedorgansystems,areinterdependentandlinked

throughsharedriskfactors.Morerecently,studiesdesignedtounraveltheintricatepathogenicmechanismsunderpinning

thisassociationshowthatpeoplewithvariouscardiacconditionsmayhavecovertbrainmicrostructuralchangesandcognitive

impairment.Thesefindingshavegivenrisetotheideathatbyaddressingcardiovascularhealthearlierinlife,itmaybe

possibletoreducetheriskofstrokeanddetertheonsetorprogressionofcognitiveimpairmentlaterinlife.Previousscientific

statementshaveaddressedtheassociationbetweencardiacdiseasesandstroke.Thisscientificstatementdiscussesthe

pathogenicmechanismsthatlink3prevalentcardiacdiseasesofadults(heartfailure,atrialfibrillation,andcoronaryheart

disease)tocognitiveimpairment.