ALT-2074-BXT-51072-生命科学试剂-MCE.pdfVIP

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

ALT-2074

Cat.No.:HY-W879508

CASNo.:173026-17-0

Synonyms:BXT-51072

分⼦式:C₁₀H₁₃NS

分⼦量:226.18

作⽤靶点:CytochromeP450;GlutathionePeroxidase

作⽤通路:MetabolicEnzyme/Protease;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性ALT-2074(BXT-51071)是⼀种具有⼝服活性的⾕胱⽢肽过氧化物酶的催化模拟物。ALT-2074是⼈源CYP3A的

抑制剂，其IC50值在2.0-2.6μM范围内。ALT-2074在体内对仅表现出对CYP3A的弱抑制作⽤，提⽰其可能

不会显著影响CYP3A底物药物的代谢。ALT-2074可⽤于研究以活性氧物种为特征的炎症性疾病，例如急性冠

状动脉综合征。

IC50TargetCYP3A

2-2.6μM(IC50)

REFERENCES

[1].GreenblattDJ,etal.Inhibitionoforalmidazolamclearancebyboostingdosesofritonavir,andby4,4-dimethyl-benziso-(2H)-selenazine

(ALT-2074),anexperimentalcatalyticmimicofglutathioneoxidase.BrJClinPharmacol.2009Dec;68(6):920-7.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

Tel:400-820-3792;021-5