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Brensocatib(Standard)

Cat.No.:HY-101056R

CASNo.:1802148-05-5

分⼦式:C₂₃H₂₄N₄O₄

分⼦量:420.46

作⽤靶点:DipeptidylPeptidase;ReferenceStandards

作⽤通路:MetabolicEnzyme/Protease;Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Brensocatib(Standard)是Brensocatib(HY-101056)的分析标准品。本产品⽤于研究及分析应⽤。

Brensocatib(AZD7986)是⼀个⼆肽基肽酶1(DPP1)抑制剂，在⼈，⼩⿏，⼤⿏，狗和兔中的pIC50值分别为

6.85,7.6,7.7,7.8和7.8[1]。

IC50TargetpIC50:6.85(humanDPP1),7.6(mouseDPP1),7.7(ratDPP1),7.8(dogDPP1),7.8(rabbitDPP1)[1]

REFERENCES

[1].DoyleK,etal.DiscoveryofSecondGenerationReversibleCovalentDPP1InhibitorsLeadingtoanOxazepaneAmidoacetonitrileBased

ClinicalCandidate(AZD7986).JMedChem.2016Oct27;59(20):9457-9472.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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