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CZ415(Standard)

Cat.No.:HY-100222R

CASNo.:1429639-50-8

分⼦式:C₂₂H₂₉N₅O₄S

分⼦量:459.56

作⽤靶点:mTOR;ReferenceStandards

作⽤通路:PI3K/Akt/mTOR;Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性CZ415(Standard)是CZ415(HY-100222)的分析标准品。本产品⽤于研究及分析应⽤。CZ415是⼀种有效的

⾼选择性mTOR抑制剂，pIC50为8.07。CZ415抑制mTORC1和mTORC2复合体。

IC50TargetpIC50:8.07(mTOR)[1]

IC50:14.5nM(pS6RP,incellularassays),14.8nM(pAKT,incellularassays),226nM(IFNγ,inwholeblood

assays)[1]

REFERENCES

[1].CansfieldAD,etal.CZ415,aHighlySelectivemTORInhibitorShowinginVivoEfficacyinaCollagenInducedArthritisModel.ACSMed

ChemLett.2016Jun10;7(8):768-73.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

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