DC-TEAD3in03-生命科学试剂-MCE.pdfVIP

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DC-TEAD3in03

Cat.No.:HY-147209

分⼦式:C₁₇H₂₄N₂O₂

分⼦量:288.38

作⽤靶点:YAP

作⽤通路:StemCell/Wnt

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性DC-TEAD3in03是⼀种亚型选择性、共价TEAD3抑制剂，其IC50为0.16μM。DC-TEAD3in03对TEAD1/2/4

的抑制活性降低100倍以上。DC-TEAD3in03在细胞内的GAL4-TEAD报告基因实验中对TEAD3的IC50为

1.15 μM，且不⼲扰β-连环蛋⽩通路。DC-TEAD3in03降低了斑马鱼尾鳍的⽣长速度。DC-TEAD3in03可⽤于

研究脊椎动物附肢的⽐例⽣长。

IC50TargetTEAD3

0.16μM(IC50)

REFERENCES

[1].LuT,etal.Discoveryofasubtype-selective,covalentinhibitoragainstpalmitoylationpocketofTEAD3.ActaPharmSinB.2021

Oct;11(10):3206-3219.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

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