D-Cys6-Asn7-D-Ala11-Cys14-Bombesin-6-14-生命科学试剂-MCE.pdfVIP

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[D-Cys6,Asn7,D-Ala11,Cys14]-Bombesin(6-14)

Cat.No.:HY-P11408

CASNo.:349657-39-2

分⼦式:C₄₄H₆₄N₁₄O₁₀S₂

分⼦量:1013.2

Sequence:{d-Cys}-Asn-Trp-Ala-Val-{d-Ala}-His-Leu-Cys-NH2(Disulfidebr

idgeCys1-Cys9)

SequenceShortening:{d-Cys}-NWAV-{d-Ala}-HLC-NH2(DisulfidebridgeCys1-Cys9)

作⽤靶点:BombesinReceptor

作⽤通路:GPCR/GProtein

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性[D-Cys6,Asn7,D-Ala11,Cys14]-Bombesin(6-14)，⼀种合成肽，是⼀种⾮选择性蛙⽪素受体(bombesin

receptor)激动剂。[D-Cys6,Asn7,D-Ala11,Cys14]-Bombesin(6-14)对神经介素B偏好的蛙⽪素受体(BB1)、

胃泌素释放肽偏好的蛙⽪素受体(BB2)和孤⼉受体(BB3)的pEC50分别为8.06、8.69和6.71。[D-

Cys6,Asn7,D-Ala11,Cys14]-Bombesin(6-14)可⽤于研究蛙⽪素受体相关疾病，如癌症、神经系统疾病等。

REFERENCES

[1].DarkerJG,etal.DiscoveryofpotentandselectivepeptideagonistsattheGRP-preferringbombesinreceptor(BB2).JPeptSci.2001

Nov;7(11):598-605.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.