DAM-001-Z236004662-生命科学试剂-MCE.pdfVIP

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DAM-001

Cat.No.:HY-179714

CASNo.:1090396-31-8

Synonyms:Z236004662

分⼦式:C₁₈H₂₃N₃O

分⼦量:297.39

作⽤靶点:DopamineTransporter

作⽤通路:NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性DAM-001(Z236004662)是⼀种强效的⾮竞争性变构抑制剂，可抑制⼈多巴胺转运蛋⽩(hDAT)，在有或⽆正

构抑制剂Nomifensine(HY-B1110)的情况下，其IC50分别为24.70μM和1.026μM[1]。

REFERENCES

[1].YeX,etal.Discoveryofanewallostericinhibitorforhumandopaminetransporterbyphysics-basedmodelingandexperimental

validation.EurJMedChem.2026Feb5;303:118403.

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