D-AP5-Standard-生命科学试剂-MCE.pdfVIP

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D-AP5(Standard)

Cat.No.:HY-100714AR

CASNo.:79055-68-8

分⼦式:C₅H₁₂NO₅P

分⼦量:197.13

作⽤靶点:iGluR;ReferenceStandards

作⽤通路:MembraneTransporter/IonChannel;NeuronalSignaling;

Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性D-AP5(Standard)是D-AP5(HY-100714A)的分析标准品。本产品⽤于研究及分析应⽤。D-AP5(D-APV)是⼀

种选择性和竞争性NMDA受体拮抗剂，Kd为1.4μM。D-AP5抑制NMDA受体的⾕氨酸结合位点。

IC50TargetNMDA[1]

REFERENCES

[1].DavisS,etal.TheNMDAreceptorantagonistD-2-amino-5-phosphonopentanoate(D-AP5)impairsspatiallearningandLTPinvivoat

intracerebralconcentrationscomparabletothosethatblockLTPinvitro.JNeurosci.1992Jan;12(1):21-34.

[2].MorrisRG,etal.N-methyl-d-aspartatereceptors,learningandmemory:chronicintraventricularinfusionoftheNMDAreceptor

antagonistd-AP5interactsdirectlywiththeneuralmechanismsofspatiallearning.EurJNeurosci.2013Mar;37(5):700-17.

[3].RHEvans,etal.Theeffectsofaseriesofomega-phosphonicalpha-carboxylic