DPP-4-IN-18-Sitagliptin-impurity-3-生命科学试剂-MCE.pdfVIP

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DPP-4-IN-18

Cat.No.:HY-Z1764

CASNo.:486460-31-5

Synonyms:Sitagliptinimpurity3

分⼦式:C₁₆H₁₆F₅N₅O

分⼦量:389.32

作⽤靶点:DipeptidylPeptidase

作⽤通路:MetabolicEnzyme/Protease

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性DPP-4-IN-18(Sitagliptinimpurity3)(Compound4)是⼀种强效、选择性且具有⼝服活性的的DPP-4抑制剂

，其IC50值为27nM。DPP-4-IN-18能有效阻⽌DPP-4降解胰⾼⾎糖素样肽-1(GLP-1)，从⽽提⾼活性GLP-1

的⽔平。DPP-4-IN-18可⽤于2型糖尿病的研究[1]。

IC50TargetDPP-4

27nM(IC50)

REFERENCES

[1].ThornberryNA,etal.DiscoveryofJANUVIA(Sitagliptin),aselectivedipeptidylpeptidaseIVinhibitorforthetreatmentoftype2diabetes.

CurrTopMedChem.2007;7(6):557-68.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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