DREADD-agonist-21-dihydrochloride-Standard-生命科学试剂-MCE.pdfVIP

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Inhibitors•ScreeningLibraries•Proteins

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DREADDagonist21dihydrochloride(Standard)

Cat.No.:HY-100234AR

CASNo.:2250025-92-2

分⼦式:C₁₇H₂₀Cl₂N₄

分⼦量:351.27

作⽤靶点:mAChR;ReferenceStandards

作⽤通路:GPCR/GProtein;NeuronalSignaling;Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性DREADDagonist21(dihydrochloride)(Standard)是DREADDagonist21(dihydrochloride)(HY-100234A)的

分析标准品。本产品⽤于研究及分析应⽤。DREADDagonist21dihydrochloride是⼀种有效的⼈毒蕈碱⼄酰

胆碱M3受体(hM3Dq)激动剂(EC50=1.7nM)[1]。

IC50TargetEC50:1.7nM(hM3Dq)[1]

pKi:5.97(hM1),5.44(hM4),7.20(hM1Dq),and6.75(hM4Di)[2]

Ki:6nM(H1histaminereceptor),66nM(5HT2Aserotoninreceptor5HT2A),170nM(5HT2Cserotonin

receptor),280nM(α1Aadrenergicreceptor)[1]

REFERENCES

[1].ChenX,etal.Thefirststructure-activityrelationshipstudiesfordesignerreceptorsexclusivelyactivatedbydesignerdrugs.ACSChem

Neurosci.2015Mar18;6(3):476-84.

[2].ThompsonKJ,etal.DREADD