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Fadraciclib(Standard)

Cat.No.:HY-101212R

CASNo.:1070790-89-4

分⼦式:C₂₁H₃₁N₇O

分⼦量:397.52

作⽤靶点:CDK;ReferenceStandards

作⽤通路:CellCycle/DNADamage;Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Fadraciclib(Standard)是Fadraciclib(HY-101212)的分析标准品。本产品⽤于研究及分析应⽤。Fadraciclib

(CYC065)是第⼆代⼝服有效的ATP竞争性的CDK2/CDK9激酶抑制剂[1]，IC50分别为5和26nM[2]。

IC50TargetCDK2/CDK9[1]

REFERENCES

[1].CoccoE,etal.DualCCNE1/PIK3CAtargetingissynergisticinCCNE1-amplified/PIK3CA-mutateduterineserouscarcinomasinvitro

andinvivo.BrJCancer.2016Jul26;115(3):303-11.

[2].SumanaDevata,etal.Molecularmarkersandvenousthromboembolism(VTE)inacutemyelogenousleukemia(AML)

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

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