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F3288-0031

Cat.No.:HY-179568

CASNo.:926493-93-8

分⼦式:C₂₄H₃₂N₂O₃

分⼦量:396.52

作⽤靶点:MonoamineTransporter

作⽤通路:MembraneTransporter/IonChannel

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性F3288-0031是⼀种去甲肾上腺素转运体(NET)变构抑制剂，在20µM浓度下抑制率为73.5%。F3288-0031

结合于NET的内腔稳定其内开⼝状态并对NET/SERT具有优先抑制活性其pIC50为5.9。F3288-0031未检测到

脱靶功能活性。F3288-0031表现出显著的抗抑郁样疗效且不伴有运动功能⼲扰。F3288-0031可⽤于抑郁症及

相关神经精神疾病的研究[1]。

体内研究F3288-0031(3-50mg/kg,i.p.,once)hasanantidepressant-likeactivitywithoutconfoundinglocomotoreffects

inC57BL/6Jmice[1].

AnimalModel:MaleC57BL/6Jmice(6-8weeks)[1]

Dosage:3,10,30,50mg/kg

Administration:i.p.,once

Result:Demonstratedadose-dependentdecreaseinimmobilitytimeintheforcedswimtest

(FST),withsignificantreductions