IPAG-Standard-生命科学试剂-MCE.pdfVIP

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IPAG(Standard)

Cat.No.:HY-100985R

CASNo.:193527-91-2

分⼦式:C₁₇H₂₂IN₃

分⼦量:395.28

作⽤靶点:SigmaReceptor;ReferenceStandards

作⽤通路:NeuronalSignaling;Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性IPAG(Standard)是IPAG(HY-100985)的分析标准品。本产品⽤于研究及分析应⽤。IPAG是⼀种有效的

sigma-1受体拮抗剂，pKi为4.3[1]。IPAG可诱导细胞凋亡(apoptosis)[2]。

REFERENCES

[1].JamesMBrimson,etal.Simpleammoniumsaltsactingonsigma-1receptorsyieldpotentialtreatmentsforcanceranddepression.Sci

Rep.2020Jun8;10(1):9251.

[2].HalleyMOyer,etal.Small-MoleculeModulatorsofSigma1andSigma2/TMEM97intheContextofCancer:FoundationalConceptsand

EmergingThemes.FrontPharmacol.2019Oct21;10:1141.

[3].FelixJKim,etal.InhibitionoftumorcellgrowthbySigma1ligandmediatedtranslationalrepression.BiochemBiophysResCommun.

2012Sep21;426(2):177-82.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.