第七章：线粒体组成与结构概述.pdfVIP

SummaryforChapterVII

Mitochondrion

1CompositionandStructure

1.1MorphologyandLocation

Themorphologyofmitochondrionvariesindifferentcells.Often,the

distributionofmitochondrionisuniform;alternatively,theyassembleinthe

regionsofhighlymetabolismandoxidation.Alsoinsomecellsmitochondrion

canformreticularstructure.

1.2ChemicalComposition

Proteinsaccountfor65%to70%ofdrybiomass,inwhichtheenzymesform

tensofenzymaticsystem,whichisrepeatedover2000timesorderly

distributedinmitochondrion.

1.3PermeabilityandSegreionofComponents

Thepermeabilityofinnermembraneismuchlowerthanthatofouterone.

Digitoninsplitstheoutermembrane,causingsegreionofoutermembrane,

substancesofintermembranespace,andmitostaftercentrifuging;the

detergentlubrolfurtherdecomposestheinnermembrane,separatingthe

vesicformedbyinnermembranefromthematrix.

1.4Structure

Theoutermembraneistheboundaryofmitochondrionwhiletheinner

membranefoldsinsidetothematrix,onwhichtherearesomeF1particle,

formingcrista.

1.5LocatingofMitochondrialProteins269

1.5.1TargetingandSortingofProteins

Proteinssynthesizedbydissociateribosomesaretranslocatedafter

completelytranslation,whichis