NCB-0846-Standard-生命科学试剂-MCE.pdfVIP

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NCB-0846(Standard)

Cat.No.:HY-100830R

CASNo.:1792999-26-8

分⼦式:C₂₁H₂₁N₅O₂

分⼦量:375.42

作⽤靶点:Wnt;ReferenceStandards;MAP4K;TGF-beta/Smad

作⽤通路:StemCell/Wnt;Others;MAPK/ERKPathway;TGF-beta/Smad

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性NCB-0846(Standard)是NCB-0846(HY-100830)的分析标准品。本产品⽤于研究及分析应⽤。NCB-0846是

⼀种⼝服有效的Wnt选择性抑制剂，可抑制Traf2和Nck相互作⽤激酶(TNIK)，IC50为21nM。NCB-0846通

过抑制SMAD2/3磷酸化和核转位来阻断TGF-β信号通路[1][2]。

IC50TargetIC50:21 nM(TNIK)[1]

REFERENCES

[1].MasudaM,etal.TNIKinhibitionabrogatescolorectalcancerstemness.NatCommun.2016Aug26;7:12586.

[2].SuganoT,etal.,Pharmacologicalblockageoftransforminggrowthfactor-βsignallingbyaTraf2-andNck-interactingkinaseinhibitor,

NCB-0846.BrJCancer.2021Jan;124(1):228-236.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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