Rev1-CT-RIR-PPI-IN-1-生命科学试剂-MCE.pdfVIP

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Rev1-CT/RIRPPI-IN-1

Cat.No.:HY-115465

CASNo.:908510-73-6

分⼦式:C₂₁H₂₉N₃O₃S

分⼦量:403.54

作⽤靶点:DNA/RNASynthesis

作⽤通路:CellCycle/DNADamage

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Rev1-CT/RIRPPI-IN-1(Compound1)是⼀种噻吩类化合物。Rev1-CT/RIRPPI-IN-1可特异性破坏Rev1-CT与

RIR的蛋⽩相互作⽤，IC50为2.5µM。Rev1-CT/RIRPPI-IN-1在Cisplatin(HY-17394)敏感的HT-1080细胞中

能增强化疗敏感性、降低突变率。Rev1-CT/RIRPPI-IN-1可⽤于肿瘤的研究。

REFERENCES

[1].OzenZ,etal.SmallmoleculescaffoldsthatdisrupttheRev1-CT/RIRprotein-proteininteraction.BioorgMedChem.2018Aug

7;26(14):4301-4309.

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