Senazodan-hydrochloride-Standard-生命科学试剂-MCE.pdfVIP

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Senazodanhydrochloride(Standard)

Cat.No.:HY-101693AR

CASNo.:98326-33-1

分⼦式:C₁₅H₁₅ClN₄O

分⼦量:302.76

作⽤靶点:Phosphodiesterase(PDE);ReferenceStandards

作⽤通路:MetabolicEnzyme/Protease;Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Senazodan(hydrochloride)(Standard)是Senazodan(hydrochloride)(HY-101693A)的分析标准品。本产品

⽤于研究及分析应⽤。Senazodan(MCI154)(hydrochloride)是⼀种Ca2+感光剂，同时可抑制PDEIII的活性

。

IC50TargetPDEIII[1]

REFERENCES

[1].LehtonenLA,etal.Pharmacokineticsandpharmacodynamicsofintravenousinotropicagents.ClinPharmacokinet.2004;43(3):187-203.

[2].ErhardtL.Anemergingroleforcalciumsensitisationinthetreatmentofheartfailure.ExpertOpinInvestigDrugs.2005Jun;14(6):659-

70.

[3].YangG,etal.EffectsofMCI-154onvascularreactivityanditsmechanismsafterhemorrhagicshockinrats.JCardiovascPharmacol.

2006;47(6):751-757.

[4].MingMJ,etal.EffectsofMCI-154,acalciumsensitizer,oncardiacdysfunctioninendotoxic