S-Deoxy-thalidomide-6-F-5-piperazine-benzenesulfonate-生命科学试剂-MCE.pdfVIP

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(S)-Deoxy-thalidomide-6-F-5-piperazinebenzenesulfonate

Cat.No.:HY-W998335

CASNo.:2504914-78-5

分⼦式:C₂₃H₂₅FN₄O₆S

分⼦量:504.53

作⽤靶点:E3LigaseLigand-LinkerConjugates

作⽤通路:PROTAC

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性(S)-Deoxy-thalidomide-6-F-5-piperazinebenzenesulfonate是⼀种E3连接酶配体-linker偶联物，包含基于

CRBN的配体和linker，可⽤于合成PROTAC。

IC50TargetCereblon

体外研究PROTACscontaintwodifferentligandsconnectedbyalinker;oneisaligandforanE3ubiquitinligaseand

theotherisforthetargetprotein.PROTACsexploittheintracellularubiquitin-proteasomesystemto

selectivelydegradetargetproteins.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

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