S-Deoxy-thalidomide-R-pyrrolidine-3-carbaldehyde-生命科学试剂-MCE.pdfVIP

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(S)-Deoxy-thalidomide-(R)-pyrrolidine-3-carbaldehyde

Cat.No.:HY-W1115222

CASNo.:2952806-82-3

分⼦式:C₁₈H₁₉N₃O₄

分⼦量:341.37

作⽤靶点:E3LigaseLigand-LinkerConjugates

作⽤通路:PROTAC

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性(S)-Deoxy-thalidomide-(R)-pyrrolidine-3-carbaldehyde是⼀种E3连接酶配体-linker偶联物，包含基于CRBN

的配体和linker，可⽤于合成PROTAC。

IC50TargetCereblon

体外研究PROTACscontaintwodifferentligandsconnectedbyalinker;oneisaligandforanE3ubiquitinligaseand

theotherisforthetargetprotein.PROTACsexploittheintracellularubiquitin-proteasomesystemto

selectivelydegradetargetproteins.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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