SDZ-FOX-988-FOX-988-生命科学试剂-MCE.pdfVIP

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Inhibitors•ScreeningLibraries•Proteins

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SDZ-FOX-988

Cat.No.:HY-19150

CASNo.:139681-18-8

Synonyms:FOX-988

分⼦式:C₂₅H₂₉NO₅

分⼦量:423.5

作⽤靶点:MitochondrialMetabolism

作⽤通路:MetabolicEnzyme/Protease

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性SDZ-FOX-988(FOX-988)是⼀种⼝服活性的抗糖尿病剂。SDZ-FOX-988螯合线粒体辅酶A去抑制carnitine

palmitoyltransferaseII。SDZ-FOX-988可诱导线粒体损伤。SDZ-FOX-988可降低⾎清β-hydroxybutyrate或

葡萄糖⽔平。SDZ-FOX-988可⽤于2型糖尿病的研究。

REFERENCES

[1].LauDT,etal.TheeffectofthefatcontentoffoodonthepharmacokineticsandpharmacodynamicsofSDZFOX988,anantidiabetic

agent,inthedog.BiopharmDrugDispos.1995Mar;16(2):137-50.

[2].VickersAE,etal.Consequencesofmitochondrialinjuryinducedbypharmaceuticalfattyacidoxidationinhibitorsischaracterizedin

humanandratliverslices.ToxicolInVitro.2006Oct;20(7):1173-82.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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