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SG3199(Standard)

Cat.No.:HY-101161R

CASNo.:1595275-71-0

分⼦式:C₃₃H₃₆N₄O₆

分⼦量:584.66

作⽤靶点:ReferenceStandards;DNAAlkylator/Crosslinker;ADC

Payload

作⽤通路:Others;CellCycle/DNADamage;Antibody-drug

Conjugate/ADCRelated

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性SG3199(Standard)是SG3199(HY-101161)的分析标准品。本产品⽤于研究及分析应⽤。SG3199是⼀种具有

细胞毒性的DNA⼩沟链间交联PBD⼆聚体。SG3199是ADC有效载荷Tesirine(SG3249)的组成成分。

REFERENCES

[1].JohnAHartley,etal.Pre-clinicalpharmacologyandmechanismofactionofSG3199,thepyrrolobenzodiazepine(PBD)dimerwarhead

componentofantibody-drugconjugate(ADC)payloadtesirine.SciRep.2018Jul11;8(1):10479.

[2].FrancescaZammarchi,etal.ADCT-402,aPBDdimer-containingantibodydrugconjugatetargetingCD19-expressingmalignancies.

Blood.2018Mar8;131(10):1094-1105.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.